Guardant Health, Which Tests for Cancer Through Blood Samples, Raises $100M In Series D Funding

Guardant Health, Which Tests for Cancer Through Blood Samples, Raises $100M In Series D Funding

Guardant Health, a three-year-old, Redwood Shores, Ca.-based company whose non-invasive genomic sequencing test for cancer requires just two vials of blood, has raised nearly $100 million in Series D funding roughly one year after closing on $90 million for its Series C round.

The financing was led by OrbiMed Advisors, with earlier backers participating, including Khosla Ventures, Sequoia Capital, Lightspeed Venture Partners, Pejman Mar, Formation 8, Heritage Group, and Felicis Ventures.

Guardant, a 135-person company that has now raised almost $200 million altogether, isn’t talking about its valuation. But cofounder and CEO Helmy Eltoukhy, a Ph.D who worked at the Stanford Genome Technology Center before cofounding and quickly selling an earlier company, talked with us yesterday about what Guardant’s investors are funding exactly. Our conversation has been edited for length.

TC: Your test alleviates the need to cut out a piece of tissue and sequence the DNA in that biopsy. Other than being less invasive, why is it better?

HE: You can take a single tumor and every part will have potentially different mutations. Through two teaspoons of blood, we can see the entirety of the disease.

TC: How has your technology changed in the last year? What prompted so much new investment?

HE: The way it works is as these tumors grow rapidly, they are also dying rapidly and shedding their content into the bloodstream, including DNA signature. [Over time] we’ve made our sequencing technology about 1,000 to 10,000 times more accurate in order to see those fragments of DNA. It’s akin to the difference between high-resolution TV and old black-and-white technologies. Because we can see those trace fragments, we can reconstruct the genome.

TC: How accurate is your blood test?

HE: It matches tissue biopsies with 99.3 percent diagnostic accuracy, and we see often more mutations [than doctors can find] in that tissue biopsy. Maybe the patient had a recent biopsy and nothing actionable was found, but now, with the mutations that we detect, that person can be given corresponding drugs that target those mutations.

TC: How many patients have used your test?

HE: Our run rate is around 20,000 patients per year now. As part of that, our knowledge of the disease is growing rapidly. Every time we sequence a patient, we find out alterations for cancer, and that’s allowing us to improve the performance of our test and the work we do with pharmaceutical companies in helping them with their targeted therapies.

TC: That’s your business model? 

HE: One part of our model is being almost a full-service partner to pharmaceutical companies across every stage of a trial, including helping them find enough patients so a trial isn’t delayed by using our massive clinical volume. During the trial, we’re monitoring patients to see why a drug is working in some and stops working in others, so we can start learning about aspects of it while the trial is ongoing and not many years later.

We’re also creating the largest database of metastatic diseases, so we can think about new targets and new drugs that may potentially be developed based on new pathways activated in patients.

Continue reading >>>