Midwest small-cap life science stocks plummet in 2005

Midwest small-cap life science stocks plummet in 2005

Although I was not at JP Morgan Healthcare Conference in San Francisco last week, I talked to several people that were and understand that it was mobbed. It used to be that people went to the conference to listen to what the presenting companies had to say, and then made their prognosis for the year. Now, as it is so attendance-jammed and hard to often get entrance to the official event, a lot of people go just to have meetings with others that are going to be there; it has become a deal-making forum on many levels.
Throughout the week, the “War of the Stents” continued, with both Boston Scientific and Johnson & Johnson both raising the ante. The stickler is that the Johnson & Johnson bid already has FTC clearance whereas the Boston Scientific bid does not, even though it is the higher bid. As of time of writing this article, it is still not clear who is the winner, although the Guidant board seems to favoring the J&J bid.
Last week’s article focused on the performance of the Midwest Large Cap Life Science group of companies and the overall stock market for the 2005. Results for 2005 showed a flat year for the major indices, with the only outlyer being the highflying Amex Biotech Stock Index, which highlights the better and biggest biotech companies. Results for the Large Cap Midwest Life Science companies was a mixed bag with 14 companies up in stock prices and 12 companies down or flat. Just to refresh your memory, let’s look a the major indices again.
Stock Market Indices – 12 Months/2005

Index

Stock Price 12/30/05

Stock Price 1/3/05

% Change
Dow Jones Industrials

10,717.50

10,783.75

<1%>
NASDAQ National

2,205.32

2,184.75

+1%
NASDAQ Biotech

790.31

770.27

+3%
AMEX Biotech

680.91

544.25

+25%

The Small Cap Midwest Life Science group literally fell off a cliff. Let’s take a look:

Midwest Small Cap Life Science Stocks – Nine Months/2005

Company/Ticker

State

Stock Price 12/30/05

Stock Price1/3/05

% Change

Market Cap $million
1. Techne (Tech)

Minnesota

$56.08

$38.90

+44%

$2,180
2. MGI Pharma (MOGN)

Minnesota

$17.16

$28.01

<39%>

$1,329
3. KV Pharmaceuticals (KV-A)

Missouri

$20.60

$22.06

<7%>

$1,016
4. eV3 (EVVV)

Minnesota

$14.74

$14.06*

+5%

$725
5. SurModics (SRDX)

Minnesota

$36.99

$32.39

+14%

$686
6. Allscripts Healthcare (MDRX)

Illinois

$13.40

$10.72

+25%

$576
7. Meridian Bioscience (VIVO)

Ohio

$20.14

$17.90

+13%

$525
8. Northfield Labs (NFLD)

Illinois

$13.40

$22.99

<42%>

$359
9. NeoPharm (NEOL)

Illinois

$10.79

$12.55

<14%>

$253
10. Stereotaxis (STXS)

Missouri

$8.61

$10.00

<14%>

$238
11. Caraco Pharmaceutical Labs (CPD)

Michigan

$8.98

$9.55

<6%>

$237
12. Aastrom Biosciences (ASTM)

Michigan

$2.11

$1.46

+45%

$217
13. Lifecore Biomedical (LCBM)

Minnesota

$16.22

$11.50

+41%

$214
14. Neogen (NEOG)

Michigan

$21.00

$22.05

<5%>

$173
15. Possis Medical (POSS)

Minnesota

$9.95

$13.52

<26%>

$172
16. Atricure (ATRC)

Ohio

$10.65

$12.10**

<12%>

$128
17. Third Wave Technologies (TWTI)

Wisconsin

$2.98

$8.73

<66%>

$123
18. Akorn (AKN)

Illinois

$4.56

$3.83

+19%

$122
19. Synovis Life Technologies (SYNO)

Minnesota

$10.03

$10.75

<7%>

$119
20. Vascular Solutions (VASC)

Minnesota

$7.56

$10.20

<26%>

$110
21. ImmTech International (IMM)

Illinois

$6.94

$12.05

<42%>

$81
22. BioSante (BPA)

Illinois

$3.65

$5.51

<34%>

$71
23. Advanced Life Sciences (ADLS)

Illinois

$3.92

$5.20***

<25%>

$68
24. Medtox Scientific (TOX)

Minnesota

$7.58

$8.90

<14%>

$62
25. Bio-Logic Systems (BLSC)

Illinois

$8.73

$9.13

<4%>

$59
26. Urologix (ULGX)

Minnesota

$3.86

$6.55

<40%>

$55
27. EnPath Medical (NPTH)

Minnesota

$8.50

$10.58

<20%>

$51
28. Tripos (TRPS)

Missouri

$2.93

$5.29

<45%>

$30
29. Aksys (AKSY)

Illinois

$0.65

$5.41

<88%>

$20
30. Avax Technologies (AVXT.OB)

Missouri

$0.25

N/A

N/A

$15
31. NeoProbe (NEOP.OB)

Ohio

$0.25

$0.59

<58%>

$14
32. Genomed (GMED.PK)

Missouri

$0.03

$0.06

<50%>

$7

*Company had its IPO on June 17th, 2005.
**Company had its IPO on Aug. 5th, 2005.
***Company had its IPO on Aug. 8th, 2005.
Well, the good news is that three Midwest companies had successful IPO’s during 2005: Atricure, Advanced Life Sciences, and eV3; however, only eV3’ stock price (+5%) was up since its IPO – the other two were down!
Another negative impact on Midwest companies was the acquisition of Bio-Logic Systems by Natus Medical (NASDAQ: BABY) for $66 million in October, 2005. As Bio-Logic has $15.3 million on its balance sheet at the end of August, the net acquisition cost was about $50 million for Natus. Natus is located in California and has a market cap of about $325 million, and markets products for the detection and monitoring of new-born babies, including hearing disorders which was the segment Bio-Logic was involved in. Hopefully, those executives of Bio-Logic Systems who have made money off this deal will re-invest in new Midwest life science companies.
This acquisition makes the 5th Midwest company to be acquired in the last 5-6 years: CIMA Labs (Cephalon), Esperion (Pfizer), Orphan Medical, Unimed (Solvay) and now Bio-Logic Systems.
Stock Performance Leaders (Outperformed NASDAQ Biotech Index):

Company

% Growth
1. Aastrom Biosciences

+45%
2. Techne

+44%
3. Lifecore Biomedical

+41%
4. Allscripts Healthcare

+25%
5. Akorn

+19%
6. SurModics

+14%
7. Meridian Bioscience

+13%
8. eV3

+5%
9. Avax Technologies

N/A

At least there is a group of companies with very solid stock performance. Aastrom Biosciences seems to have been revived from the dead and had outstanding performance as did Techne, Lifecore Biomedical, Allscripts, and Akorn which underwent significant restructuring.
Stock Performance Laggards (Underperformed NASDAQ Biotech Index):

Company

% Decline
1. Aksys

<88%>
2. Third Wave Technologies

<66%>
3. Neoprobe

<58%>
4. Genomed

<50%>
5. Tripos

<45%>
6. Northfield Labs

<42%>
7. Immtech International

<42%>
8. Urologix

<40%>
9. MGI Pharma

<39%>
10. BioSante

<34%>
11. Possis Medical

<26%>
12. Vascular Solutions

<26%>
13. Advanced Life Sciences

<25%>
14. Enpath Medical

<20%>
15. NeoPharm

<14%>
16. Stereotaxis

<14%>
17. Medtox Scientific

<14%>
18. Atricure

<12%>
19. KV Pharmaceuticals

< 7%>
20. Synovis Life Technologies

< 7%>
21 Caraco Pharmaceuticals Labs

< 6%>
22. Neogen

< 5%>
23. Bio-Logic Systems

< 4%>

Let’s hope that 2006 brings calmer waters for Midwest Life Science companies. Hopefully the BIO 2006 Annual meeting in Chicago will bring renewed interest in Midwest companies in terms of investments, and business development deals.
See you next week!

Michael S. Rosen is president of Rosen Bioscience Management, a company that provides CEO services including financing, business and corporate development to start-up and early stage life science companies such as Renovar and Immune Cell Therapy. Rosen is also a founder and board member of the Illinois Biotechnology Industry Organization. He can be reached at rosenmichaels@aol.com.
This article has been syndicated on the Wisconsin Technology Network courtesy of ePrairie, a user-driven business and technology news community distributed via the Web, the wireless Web and free daily e-mail newsletters.
The opinions expressed herein or statements made in the above column are solely those of the author and do not necessarily reflect the views of The Wisconsin Technology Network, LLC. (WTN). WTN, LLC, accepts no legal liability or responsibility for any claims made or opinions expressed herein.